CBD Research Library

Due to the century long war on drugs, Cannabidiol (CBD) research is far behind many other medical advancements. In fact, it's really still in its infancy with only roughly 1,500 medical studies being completed to date on cannabis and/or CBD based products and treatments.  

The wonderful thing is once the floodgates opened research has developed quickly. New studies are coming out weekly. CBD research is now a multimillion dollar industry, with clinical trials being conducted at some of the top research facilities and institutes in the world. CBD is helping millions live a more pain free, healthy life. 

The research community is so interested in CBD, because the potential health benefits are clear. Plus, the side effects of using a potent CBD are minimal compared to harsher medical prescription drugs. 

Read Our Pet CBD Buyer's Guide to Learn More >> 

If you're on the fence about adding CBD into your pet's routine check out this infographic of top research quotes and take some time to read through the incredible studies below in our CBD research library. 

We’ve broken it down per symptom. 

Furry Friends & CBD

It is clear a lot more research needs to be completed in regards to animal use of CBD. However, new studies have recently surfaced showing the incredible benefits. Pet owners from all over the world are reporting significant improvements in their pet’s health after using CBD. 

Learn more below. 

Pet Research:

-Seizure Reduction in Dogs

-Pharmacokinetics of cannabidiol in dogs

-Natures medicine: hemp derived CBD for anxious pets

-Denver news release: CBD for pets

-Treating seizures in pets with CBD 

-CBD dog treats real and amazing things 

-PETA: Article about pets and the use of cannabis

-Hemp CBD Oil and Treats are all the Rage; Can CBD benefit your dog?

Pain Management Using CBD

Research for a variety of types of pain management has been completed including pain from nerve damage and diseases such as Multiple Sclerosis. 

The results are extremely hopeful that CBD can help both humans and animals alike with different types of pain management from mil to severe. 

Pain Management Studies:

-Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain
-Investigation of Cannabis for Chronic Pain and Palliative Care

-Cannabinoids in the management of difficult to treat pain

-An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics.

-A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis.

-Pain relief with cannabinoids– the importance of endocannabinoids and cannabinoids for pain therapy

Meta analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain

Arthritis & CBD

While Arthritis is a type of pain, we’re keeping it separate here because the studies are so strong for this particular issue. Both humans and pets suffer from this type of pain. Arthritis is seen most prominently in older pets.

Here’s the research on how the use of a quality CBD could help revitalize your pet’s ability to move, jump and play. 

Arthritis Studies:

-Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis

-The abnormal cannabidiol analog O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55.

-Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw.

-Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.

-Therapeutic potential of cannabinoid-based drugs.

-Involvement of the Endocannabinoid System in Osteoarthroid Pain

-Transdermal cannabidiol reduces inflammation and pain-related behaviors in a rat model of arthritis.

CBD Healing for Seizures & Epilepsy

Seizures are terrifying and potentially deadly attacks to the brain and nervous system. Cannabis and CBD studies alike are showing HUGE strides in the medical treatment of seizures and diseases like Epilepsy. 

From adults to children to pets the results reveal CBD not only limits the length and severity of seizures, it may even prevent future seizures. 

Seizure and Epilepsy Studies: 

-Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?

-Cannabidiol (CBD) significantly reduces drop seizure frequency in Lennox-Gastaut syndrome

-A Randomized Control Trial of Cannabidiol (GWP42003-P, CBD) for Seizures in Tuberous Sclerosis Complex 

-Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

-Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy.

-Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.

-Cannabidiol–antiepileptic drug comparisons and interactions in experimentally induced seizures in rats.

-Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo.

-Cannabidiol–antiepileptic drug comparisons and interactions in experimentally induced seizures in rats.

CBD Treatment for Mental Health, Anxiety & Sleep 

Since CBD was first discovered for its medical benefits it has been studied heavily for its effects on mood including depression and anxiety. In fact, today many therapists prescribe a CBD based supplement to their patients. 

Research is showing treatment with CBD can help both humans and pets live more comfortable lives. It is particularly helpful for animals with severe travel or sound-based anxieties. 

Anxiety, Mental Health and Sleep Studies:

-Cannabidiol in Anxiety and Sleep: A Large Case Series

-Cannabidiol as a Potential Treatment for Anxiety Disorders

-Antidepressant-like and Anxiolytic-like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa

-The Endocannabinoid System and the Treatment of Mood and Anxiety Disorders

-Endocannabinoid System Dysfunction in Mood and Related Disorders

- Lancet 1997;349:1498-504. [PubMed

-A Systematic review of plant-derived natural compounds for Anxiety Disorders

-Does Cannabidiol Protect Against Adverse Psychological Effects of THC?

-Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence

-Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives

CBD Helping Cancer & Chemotherapy Symptoms 

Any person or creature suffering from cancer knows just how devastating the effects can be. Chemotherapy and radiation treatments can leave your furry friend sicker than before. Hopeful research is coming out showing CBD’s potential for easing symptoms like nausea and lack of appetite. Some studies even show signs daily use of a quality CBD can shrink tumors. 

Cancer Research:

-The current state and future perspectives of cannabinoids in cancer biology

-Cannabinoids for Cancer Treatment: Progress and Promise

-Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect.

-Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells.

-Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol.

-Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of p22phox and Nox4 Expression

-Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents

-Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma

-Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy

-Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpesvirus-infected endothelium.

-Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells